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Title
2-D NMR Developments Improve Monoclonal Antibody Characterization
Monday, September 26, 2016
Kimberly L. Colson
Ten years ago, industry commentators noted the increasing importance of biologics, and monoclonal antibodies (mAbs), in particular.
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A Clearer View of 3-D Cell Culture: Optimizing Fluorescence Imaging and Analysis
Tuesday, December 01, 2015
Cecile Villemant
Grant Cameron
Jenny Schroeder
The study of cells in two-dimensional (2-D) culture systems, usually in a well plate or in a flask, has contributed to the understanding of many biological processes.
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A Matter of Speed: Real-Time PCR for the Rapid Detection of Mycoplasma Contamination
Wednesday, June 11, 2014
Stephanie Schweizer
Alexandra Scholz
Mycoplasma are among the world’s smallest bacteria capable of independent reproduction. They belong to the class of Mollicutes and have a very slow and parasitic growth.
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A Novel Hydrogel-Based Approach for Cell Isolation, Purification and Release
Monday, February 22, 2016
Andrea Armstead
The purification and enrichment of specific cell populations from complex starting samples is a critical component of multiple life science workflows.
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A Portable CGE-Based Biomolecule Detection System Using a Smartphone App for Operation via WiFi
Monday, October 27, 2014
Varouj Amirkhanian
Eric Tsai
Allen Chi
Myron Yu
Hsinhan Huang
Most bioseparation and detection tools used in the laboratory employ slab gel-based electrophoresis technologies, which have routinely been used for the analysis of biomolecules (i.e., DNA, RNA, ...
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A Redesigned Confocal Microscope for Super-Resolution Microscopy
Tuesday, May 09, 2017
Erik Manders
Peter Drent
Ronald Breedijk
A simple optical redesign converts a standard confocal microscope to a super-resolution microscope.
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A Review of Quetzal: A Linguistic Search Engine for Biomedical Literature
Wednesday, August 05, 2015
C. Tobin Magle
Quetzal is a biomedical literature search engine that uses simple strategies that contain few keywords combined with an extensive biomedical vocabulary and filter sets that mirror the discovery ...
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Achieving Accuracy and Reproducibility With Electronic Pipettes
Monday, November 07, 2016
Nora Meneceur
Beatrice Guieu-Presle
Researchers are continuously seeking ways to improve efficiency while ensuring that their methods are reliable and their research is reproducible.
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An Automated System to Improve Western Blot Processing
Wednesday, April 22, 2015
Alexander Margulis
Angela M. Zaorski
David P. Chimento
Russ Yukhananov
Western blot assays provide important information about the presence and levels of protein expression. The first step in the procedure is the lysis of cells or tissues followed by solubilization of ...
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An Improved Method to Generate Virus-Free Human iPSCs
Monday, November 03, 2014
Vi Chu
Nick Asbrock
Min Lu
Induced pluripotent stem cells (iPSCs) are offering new opportunities in both research and clinical applications. Researchers are using these cells for drug and toxicity screening, as well as for ...
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Antibody Labeling Method Eliminates Column Purification Step
Tuesday, May 31, 2016
Chris Linnevers
Labeling and purifying antibodies in-house can be a multi-step process.
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Automated Cell Staining in Drug Discovery
Tuesday, April 09, 2013
Amy Yoder
Li Liu
Cell and molecular biology become more integral pieces of the modern drug discovery process on a seemingly daily basis. Monitoring the interaction of cells and internal cellular activity provides ...
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Automated Chromatographic Solid-Phase Extraction Using an Autosampler
Thursday, September 01, 2016
Mark Hayward
Jonathan Ho
Rick Youngblood
Matthew T. Hardison
Tom Moran
Kim Gamble
Solid-phase extraction (SPE) is a preferred tool for isolating target analytes from complex matrices because the availability of a diverse range of chromatographic sorbents enables targeted approaches...
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Automated Colony Counting: A Critical Requirement for Advanced Cancer Research
Monday, February 10, 2014
Michael Rau
The colony counting method has long been recognized as the primary method for measuring the effects of radiation, chemotherapeutic drugs, and other agents on cell viability.
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Automated Liquid Handling Robots: Bridging the Gap Between Nanoliter Liquid Handling and Larger Volume Dispensing
Wednesday, March 06, 2013
Wendy Gaisford
The introduction of automated nanoliter volume liquid handling instrumentation has revolutionized work flows, reducing the tedium of manual pipetting and the potential for manual error. In addition, ...
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Automated Molecular Biology
Tuesday, May 10, 2016
Alan H. Katz
Lower costs and increased speeds have led researchers sequencing genes and genomes to generate an enormous amount of data that can provide a better understanding of diseases.
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Automated Sample Preparation Using a Dual-Arm Robotic Platform
Monday, May 02, 2016
Heidi Fleischer
Kerstin Thurow
Thomas Roddelkopf
Xianghua Chu
Norbert Stoll
Michael Klos
As described in this article, the CSDA10F dual-arm robot can utilize pipets, syringes, vials, microplates and thermal shakers (including pipets and a thermal shaker designed for manual use) to prepare...
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Automating 3-D Cell Culture and Screening by Flow Cytometry and High-Content Imaging
Friday, November 04, 2016
Michael Kowalski
For over half a century, researchers have used 2-D cell culture methods, though the physiological relevance of these models has frequently been in doubt, largely because monolayer culture systems ...
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Automating and Validating Analysis in High-Throughput Single-Cell Assays
Monday, June 15, 2015
Ian Taylor
Jay Almarode
Michael D. Stadnisky
While genomics and transcriptomics provide insight into the potential of a cell, single-cell phenomic data reflect its current reality, allowing researchers to determine how genomic variants affect ...
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Automation Enhances Next-Generation Sequencing Workflows
Wednesday, January 27, 2016
Pierre Varineau
Steve Siembieda
Powerful next-generation sequencing (NGS) platforms have led to the development of large-scale genome initiatives like the 100,000 Genomes Project, The Cancer Genome Atlas (TCGA), International ...
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